Hydrochloric Acid → 3-Benzyl-2-carbamoylimino-thiazolidine

HRID 2290258Notes

Reaction equation

HRID 2290258 reaction equation
[CH2:1]([N:8]1[CH2:12][CH2:11][S:10][C:9]1=[N:13][C:14]#[N:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[OH-:17].[NH4+]>>[CH2:1]([N:8]1[CH2:12][CH2:11][S:10][C:9]1=[N:13][C:14](=[O:17])[NH2:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14923Ammonium HydroxideHCID 14306192(3-Benzyl-1,3-thiazolidin-2-ylidene)cyanamide

Product 1

HCID 536374353-Benzyl-2-carbamoylimino-thiazolidine

Procedure

6.36 g (50 moles) of 3-benzyl-2-cyanimino-thiazolidine are boiled with 80 ml of a 10% hydrochloric acid for 10 minutes. A clear solution is obtained, which is cooled down and alkalized with a 25% aqueous ammonium hydroxide solution to yield 5.65 g of 3-benzyl-2-carbamoylimino-thiazolidine, melting at 143° to 145° C. After crystallization from ethanol the melting point is raised to 148° C.

Workup

  1. customA clear solution is obtained
  2. temperaturewhich is cooled down

Sources & evidence

ORD record
ord-f0b59c1fb0ca464aadc81968708a28ed
Source dataset
uspto-grants-1986_10
Patent number
US04616025

Reaction notes

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