反应详情

A mixture of 9.4 g. (50 mmole) 4-chlorocinnamyl chloride and 13.1 g. (50 mmole) n-butyl 4-(piperazin-1-yl)-benzoate in 40 ml. hexamethylphosphoric acid triamide is heated for 10 hours to 60° C., 6.9 g. (50 mmole) potassium carbonate are added thereto and stirring continued for 5 hours at 60° C. After cooling, the reaction mixture is diluted with the tenfold amount of water, the organic components are taken up in ethyl acetate and the dried ethyl acetate solution is evaporated. The residue is recrystallised from methanol to give 10.0 g. (48%) of desired product; m.p. 115°-117° C. The hydrochloride melts at 166°-168° C.

1. additionA mixture of 9.4 g
2. temperatureAfter cooling
3. customthe dried ethyl acetate solution is evaporated
4. customThe residue is recrystallised from methanol
5. customto give 10.0 g