反应详情

A mixture of 8.2 g. (37 mmole) 1-(2-phenoxypropyl)-piperazine, 9.57 g. (37 mmole) ethyl 4-(2-bromoethyl)-benzoate, 3.77 g. (37 mmole) triethylamine and 100 ml. anhydrous tetrahydrofuran is heated for 36 hours at reflux temperature and then evaporated. The residue is taken up in diethyl ether and the hydrochloride precipitated from this solution with hydrogen chloride-containing diethyl ether to give 14.7 g. (84% of theory) of the desired compound as a hydrochloride; m.p. 232° C.

1. additionA mixture of 8.2 g
2. temperatureat reflux temperature
3. customevaporated
4. customthe hydrochloride precipitated from this solution with hydrogen chloride-
5. additioncontaining diethyl ether
6. customto give 14.7 g