Piperidine-2-methylamine → Flecainide

HRID 2290642Notes

Reaction equation

HRID 2290642 reaction equation
[F:1][C:2]([F:21])([F:20])[CH2:3][O:4][C:5]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:10][C:6]=1[C:7](Cl)=[O:8].[NH2:22][CH2:23][CH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][NH:25]1>>[F:1][C:2]([F:21])([F:20])[CH2:3][O:4][C:5]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:10][C:6]=1[C:7]([NH:22][CH2:23][CH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][NH:25]1)=[O:8]

Participants

3

Reactant 2

HCID 90865Piperidine-2-methylamineHCID 11427683Benzoyl chloride, 2,5-bis(2,2,2-trifluoroethoxy)-

Product 1

HCID 3356Flecainide

Procedure

contacting the resultant 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid chloride with 2-aminomethylpiperidine, whereby there is formed 2,5-bis(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)benzamide.

Sources & evidence

ORD record
ord-60e09ac26b314c34948c38d384f34d22
Source dataset
uspto-grants-1986_10
Patent number
US04617396

Reaction notes

Loading…