Potassium Carbonate → Indoline

HRID 2290645Notes

Reaction equation

C(=O)([O-])[O-].[K+].[K+].C[C:8]1[C:14](=O)[C:13]2[N:16]3[C@@:20](OC)([C@H:21](COC(N)=O)[C:12]=2[C:10](=O)[C:9]=1OC)[C@H]1N[C@H]1C3>>[NH:16]1[C:13]2[C:12](=[CH:10][CH:9]=[CH:8][CH:14]=2)[CH2:21][CH2:20]1

Participants

Reactant 2

HCID 11430Potassium Carbonate

HCID 19972Mitomycin A

Product 1

HCID 10328Indoline

Procedure

This compound was prepared by the procedure described in Example 1, except that the potassium carbonate was omitted. From 100 mg. of mitomycin A and 69 mg. of indoline was obtained 45 mg. (36% yield) of the desired product having a melting point of 127°-135° C. (decomposition) and providing the following analysis:

Workup

customThis compound was prepared by the procedure

Sources & evidence

ORD record: ord-b541dbea14854d349473eaaefa000f15
Source dataset: uspto-grants-1986_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04617389

Reaction notes

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