Potassium Carbonate → 1,3-Benzodioxol-5-amine

HRID 2290647Notes

Reaction equation

C(=O)([O-])[O-].[K+].[K+].C[C:8]1[C:14](=O)[C:13]2[N:16]3[C@@](OC)([C@H](COC(N)=O)[C:12]=2[C:10](=[O:11])[C:9]=1[O:30][CH3:31])[C@H]1N[C@H]1C3>>[CH2:31]1[O:30][C:9]2[CH:8]=[CH:14][C:13]([NH2:16])=[CH:12][C:10]=2[O:11]1

Participants

Reactant 2

HCID 11430Potassium Carbonate

HCID 19972Mitomycin A

Product 1

HCID 843101,3-Benzodioxol-5-amine

Procedure

This compound was prepared by the procedure described in Example 1, except that the potassium carbonate was omitted. From 80 mg. of mitomycin A and 0.1 ml. of 3,4-methylenedioxyaniline was obtained 50 mg. (48% yield) of the desired product having a melting point of 86°-88° C. (decomposition) and providing the following analysis:

Workup

customThis compound was prepared by the procedure

Sources & evidence

ORD record: ord-1cbc687263b44bd091db86cd79eaae41
Source dataset: uspto-grants-1986_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04617389

Reaction notes

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