Ethanamine, 2-fluoro-, hydrochloride → HCID 20231566, compound

HRID 2290648Notes

Reaction equation

HRID 2290648 reaction equation
Cl.[F:2][CH2:3][CH2:4][NH2:5].C[O-].[Na+].[CH3:9][C:10]1[C:16](=[O:17])[C:15]2[N:18]3[C@@:22]([O:29][CH3:30])([C@H:23]([CH2:24][O:25][C:26]([NH2:28])=[O:27])[C:14]=2[C:12](=[O:13])[C:11]=1OC)[C@H:21]1[NH:31][C@H:20]1[CH2:19]3.C(=O)([O-])[O-].[K+].[K+]>CO>[C:26](=[O:25])([OH:27])[NH2:28].[OH:25][CH2:24][CH:23]1[C:14]2[C:12](=[O:13])[C:11]([NH:5][CH2:4][CH2:3][F:2])=[C:10]([CH3:9])[C:16](=[O:17])[C:15]=2[N:18]2[CH2:19][CH:20]3[NH:31][CH:21]3[C:22]12[O:29][CH3:30]

Participants

6

Reactant 4

HCID 9995Ethanamine, 2-fluoro-, hydrochlorideHCID 11430Potassium CarbonateHCID 19972Mitomycin AHCID 10942334Sodium Methoxide

Product 1

HCID 20231566HCID 20231566, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared by the procedure described in Example 1, except that the 2-fluoroethylamine hydrochloride (220 mg.) was neutralized with sodium methoxide (119 mg.) in 2 ml. of methanol at 5° C. before the mitomycin A (77 mg.) was added, and potassium carbonate was not used. A 62 mg. (74%) yield of the desired product was obtained, having no melting point below 340° C. and providing the following analysis:

Workup

  1. customThis compound was prepared by the procedure

Sources & evidence

ORD record
ord-cb270f2fd028474ca8e960d3eabecd14
Source dataset
uspto-grants-1986_10
Patent number
US04617389

Reaction notes

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