Phenyl Isothiocyanate → HCID 53792735, compound

HRID 2290735Notes

Reaction equation

HRID 2290735 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]([CH3:15])[NH:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1.[C:16]1([N:22]=[C:23]=[S:24])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>CN(C)C=O>[C:16]1([NH:22][C:23](=[S:24])[NH:1][C:2]2[CH:3]=[CH:4][C:5]([C:8]3[CH:9]([CH3:15])[NH:10][C:11](=[O:14])[NH:12][N:13]=3)=[CH:6][CH:7]=2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 7673Phenyl IsothiocyanateHCID 133860336-(4-aminophenyl)-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one

Product 1

HCID 53792735HCID 53792735, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 6-(4-aminophenyl)-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (3 g) and phenyl isothiocyanate (1.8 ml) in dimethylformamide (30 ml) was stirred at room temperature for 6 hours and then concentrated under reduced pressure. To the residue was added water and the thus-produced crystals were recovered by filtration, washed with water and dried to give 6-[4-(3-phenyl-thioureido)phenyl]-5-methyl-4,5-dihydro-1,2,4-triazin-3(2H)-one (5.32 g).

Workup

  1. concentrationconcentrated under reduced pressure
  2. additionTo the residue was added water
  3. filtrationthe thus-produced crystals were recovered by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-8a86716064cc433da7b3a4fa5418b651
Source dataset
uspto-grants-1986_10
Patent number
US04618610

Reaction notes

Loading…