Ethanesulfonyl chloride → Ethanesulfonic acid;7-hydroxy-3,4-dimethylchromen-2-one

HRID 2290764Notes

Reaction equation

HRID 2290764 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:14])=[C:7]([CH3:13])[C:8](=[O:12])[O:9]2)=[CH:4][CH:3]=1.[CH2:15]([S:17](Cl)(=[O:19])=[O:18])[CH3:16]>O.[OH-].[Na+]>[CH2:15]([S:17]([OH:19])(=[O:1])=[O:18])[CH3:16].[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:14])=[C:7]([CH3:13])[C:8](=[O:12])[O:9]2)=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 11667Ethanesulfonyl chlorideHCID 54129907-hydroxy-3,4-dimethyl-2H-chromen-2-one

Product 1

HCID 86741079Ethanesulfonic acid;7-hydroxy-3,4-dimethylchromen-2-one

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 14798Sodium HydroxideSolvent

Procedure

5.0 g of 7-hydroxy-3,4-dimethylcoumarin were dissolved in 20 ml of H2O/1.1 g of NaOH at room temperature, while stirring, and 3.4 g of ethanesulfonyl chloride were added. The mixture was stirred overnight, and the precipitate was filtered off under suction and recrystallized from ethanol.

Workup

  1. stirringThe mixture was stirred overnight
  2. filtrationthe precipitate was filtered off under suction
  3. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-6ef9b4ad9f104ef58760f70b6ee8b4cf
Source dataset
uspto-grants-1986_10
Patent number
US04618622

Reaction notes

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