4-Piperidinol, 1,2,2,6,6-pentamethyl- → HCID 20230532, compound

HRID 2290786Notes

Reaction equation

HRID 2290786 reaction equation
Cl[CH2:2][C:3]([N:5]([CH:27]1[CH2:32][C:31]([CH3:34])([CH3:33])[NH:30][C:29]([CH3:36])([CH3:35])[CH2:28]1)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]([C:23](=[O:26])[CH2:24]Cl)[CH:13]1[CH2:18][C:17]([CH3:20])([CH3:19])[NH:16][C:15]([CH3:22])([CH3:21])[CH2:14]1)=[O:4].[CH3:37][N:38]1[C:43]([CH3:45])([CH3:44])[CH2:42][CH:41]([OH:46])[CH2:40][C:39]1([CH3:48])[CH3:47].[Na]>C1(C)C(C)=CC=CC=1>[CH3:37][N:38]1[C:43]([CH3:44])([CH3:45])[CH2:42][CH:41]([O:46][CH2:2][C:3]([N:5]([CH:27]2[CH2:32][C:31]([CH3:34])([CH3:33])[NH:30][C:29]([CH3:36])([CH3:35])[CH2:28]2)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]([C:23](=[O:26])[CH2:24][O:46][CH:41]2[CH2:40][C:39]([CH3:47])([CH3:48])[N:38]([CH3:37])[C:43]([CH3:45])([CH3:44])[CH2:42]2)[CH:13]2[CH2:18][C:17]([CH3:20])([CH3:19])[NH:16][C:15]([CH3:22])([CH3:21])[CH2:14]2)=[O:4])[CH2:40][C:39]1([CH3:48])[CH3:47]

Participants

5

Reactant 3

HCID 754724-Piperidinol, 1,2,2,6,6-pentamethyl-2×HCID 5360545SodiumHCID 19828245HCID 19828245, compound

Product 1

HCID 20230532HCID 20230532, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent2×

Procedure

38.29 g (0.07 mol) of N,N'-bis-(2-chloroacetyl)-N,N'-bis-(2,2,6,6-tetramethyl-piperidin-4-yl)-1,6-diaminohexane are dissolved in 100 ml of anhydrous xylene. The solution thus obtained is cooled to 0°-10° C.; the solution of 29.72 g (0.154 mol) of the sodium alcoholate of 1,2,2,6,6-pentamethyl-piperidin-4-ol in 120 ml of xylene (obtained beforehand by reacting 3.54 g (0.154 mol) of sodium with 26.38 g (0.154 mol) of 1,2,2,6,6-pentamethyl-piperidin-4-ol in 120 ml of anhydrous xylene) is then added slowly with continuous stirring.

Workup

  1. customThe solution thus obtained
  2. temperatureis cooled to 0°-10° C.

Sources & evidence

ORD record
ord-4dbc2799016441c9bfad101807ae7151
Source dataset
uspto-grants-1986_10
Patent number
US04618634

Reaction notes

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