Ebselen → HCID 13711825, compound

HRID 2290789Notes

Reaction equation

HRID 2290789 reaction equation
[C:1]1([N:7]2[C:11](=[O:12])[C:10]3[CH:13]=[CH:14][CH:15]=[CH:16][C:9]=3[Se:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:17][C@@H:18]([C:23]([OH:25])=[O:24])[C:19]([SH:22])([CH3:21])[CH3:20]>CO.CN(C)C=O.O>[C:1]1([NH:7][C:11]([C:10]2[CH:13]=[CH:14][CH:15]=[CH:16][C:9]=2[Se:8][S:22][C:19]([CH3:21])([CH3:20])[C@H:18]([C:23]([OH:25])=[O:24])[NH2:17])=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

6

Reactant 2

HCID 3194EbselenHCID 5852Penicillamine

Product 1

HCID 13711825HCID 13711825, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 962WaterSolvent2×HCID 6228DimethylformamideSolvent

Procedure

5 g (18,2 mmol) 2-phenyl-1,2-benzoisoselenazole-3-(2H)-one are dissolved in 250 ml methanol and 30 ml dimethylformamide. A solution of 2,71 g (18,2 mmol) D-penicillamine in 100 ml water is added while stirring. To this clear solution, so much water is added until a slight haze is to be seen. After stirring for 18 hours, the precipitate is filtered and recristallized from ethanol/water (3:2).

Workup

  1. stirringAfter stirring for 18 hours
  2. filtrationthe precipitate is filtered

Sources & evidence

ORD record
ord-d75b7f60073d4453b126e91470593064
Source dataset
uspto-grants-1986_10
Patent number
US04618669

Reaction notes

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