HCID 54299121, compound → 1-Bromooctane
Reaction equation
C(O[C:9]1[CH:10]=[C:11]([CH2:23][CH:24]=O)[CH:12]=[CH:13][C:14]=1OCC1C=CC=CC=1)C1C=CC=CC=1.C([Mg:34][Br:35])CCCCCCC>CCOCC>[Mg:34].[CH2:10]([Br:35])[CH2:9][CH2:14][CH2:13][CH2:12][CH2:11][CH2:23][CH3:24]Participants
5
Reactant 2
Product 2
Reagents, catalysts & solvents 1
Procedure
After gradually adding 0.5 g of 3,4-dibenzyloxyphenylacetaldehyde to 10 mg of an ether solution of n-octylmagnesium bromide obtained from 0.12 g of magnesium and 0.97 g of n-octyl bromide, the mixture was stirred for 30 minutes at room temperature. To the reaction mixture thus obtained was added 10 ml of an aqueous 5% hydrochloric acid solution and after stirring the mixture, the ether layer was collected. The ether solution was washed with water, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to provide 0.5 g of 1-(3,4-dibenzyloxyphenyl)-2-decanol.
Sources & evidence
- ORD record
- ord-02fad9fc63b9482db7d0bbc5e4edd2d6
- Source dataset
- uspto-grants-1986_10
- Patent number
- US04618627
Reaction notes
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