反应详情

A mixture of 0.5 g of 6-(3,4-dibenzyloxyphenyl)hexyl bromide, 0.12 g of acetylacetone, 0.15 g of potassium carbonate, 0.02 g of sodium iodide, and 5 ml of ethanol was refluxed for 20 hours. To the reaction mixture was added 15 ml of water and the product was extracted with 20 ml of ether. The extract was washed with water, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to provide a sticky product. The product was applied to silica gel (45 ml) column chromatography and eluted with a mixture of toluene and ethyl acetate (30:1) to provide 33 mg of 9-(3,4-dibenzyloxyphenyl)-2-nonanone as an oil.

1. temperaturewas refluxed for 20 hours
2. extractionthe product was extracted with 20 ml of ether
3. washThe extract was washed with water
4. dry with materialdried over anhydrous magnesium sulfate
5. concentrationconcentrated under reduced pressure
6. customto provide a sticky product
7. washeluted with a mixture of toluene and ethyl acetate (30:1)