3,4-Bis(benzyloxy)benzaldehyde → HCID 13565957, compound

HRID 2290814Notes

Reaction equation

HRID 2290814 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][C:16]=1[O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH:12]=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:25][C:26]1([CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37]Br)OCC[O:27]1.[Mg]>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:12](=[O:13])[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][C:26](=[O:27])[CH3:25])[CH:14]=[CH:15][C:16]=1[O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 795263,4-Bis(benzyloxy)benzaldehydeHCID 5462224MagnesiumHCID 19823699HCID 19823699, compound

Product 1

HCID 13565957HCID 13565957, compoundYield 18.5%

Procedure

By following the procedure as in Reference Example 25 using a Grignard reagent prepared from 3 g of 3,4-dibenzyloxybenzaldehyde, 2.5 g of 2-methyl-(7-bromoheptyl)-1,3-dioxolane, and 0.3 g of magnesium, 0.8 g of 1-(3,4-dibenzyloxyphenyl)-1,9-decanedione was obtained.

Sources & evidence

ORD record
ord-58e65a48d968486cabd3e8a0ba65a118
Source dataset
uspto-grants-1986_10
Patent number
US04618627

Reaction notes

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