Triethylamine → HCID 13290240, compound

HRID 2291011Notes

Reaction equation

HRID 2291011 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([NH:6][CH2:7][CH3:8])=[CH:4][CH:3]=1.C(N(CC)CC)C.[Cl:18][C:19]1[N:24]=[C:23](Cl)[C:22]([CH:26]=[O:27])=[C:21]([Cl:28])[N:20]=1>O1CCCC1>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([N:6]([C:23]2[N:24]=[C:19]([Cl:18])[N:20]=[C:21]([Cl:28])[C:22]=2[CH:26]=[O:27])[CH2:7][CH3:8])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 5878414-chloro-N-ethylanilineHCID 109327462,4,6-Trichloro-5-pyrimidinecarboxaldehyde

Product 1

HCID 13290240HCID 13290240, compoundYield 72.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Solutions of 15.56 g (0.1 mole) of 4-chloro-N-ethylaniline (III) and 11.13 g (0.11 mole) of triethylamine, in each case in 50 ml of tetrahydrofuran, were successively added dropwise to a solution of 21.14 g (0.1 mole) of 2,4,6-trichloropyrimidine-5-carbaldehyde (II) in 100 ml of tetrahydrofuran. The solution was then stirred for three hours at room temperature and the triethylammoniumchloride was filtered off. The filtrate was then evaporated in vacuo and stirred with 150 ml of methanol at 0° C. 23.9 g of colorless crystals were obtained.

Workup

  1. filtrationthe triethylammoniumchloride was filtered off
  2. customThe filtrate was then evaporated in vacuo
  3. stirringstirred with 150 ml of methanol at 0° C

Sources & evidence

ORD record
ord-72367fbf2f7d43a9a7dcdb485971a387
Source dataset
uspto-grants-1986_10
Patent number
US04619885

Reaction notes

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