Hydrochloric Acid → HCID 20031799, compound

HRID 2291295Notes

Reaction equation

HRID 2291295 reaction equation
C([O:4][C:5]1[CH:24]=[CH:23][C:8]([C:9]([O:11][C:12]2[C:17]([F:18])=[C:16]([F:19])[C:15]([F:20])=[C:14]([F:21])[C:13]=2[F:22])=[O:10])=[CH:7][CH:6]=1)(=O)C.Cl>O1CCCC1>[OH:4][C:5]1[CH:24]=[CH:23][C:8]([C:9]([O:11][C:12]2[C:13]([F:22])=[C:14]([F:21])[C:15]([F:20])=[C:16]([F:19])[C:17]=2[F:18])=[O:10])=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20031857HCID 20031857, compound

Product 1

HCID 20031799HCID 20031799, compoundYield 91.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Pentafluorophenyl 4-acetoxybenzoate (10 g) in tetrahydrofuran was treated with 50 ml of 5M hydrochloric acid and 150 ml of tetrahydrofuran and stirred at room temperature overnight. The solvents were evaporated in vacuo to give a product which was purified by column chromatography (silica; ethyl acetate/hexane mixtures as eluant) to afford the title compound (8 g).

Workup

  1. customThe solvents were evaporated in vacuo
  2. customto give a product which
  3. customwas purified by column chromatography (silica; ethyl acetate/hexane mixtures as eluant)

Sources & evidence

ORD record
ord-f0eba863e7a149a8a74543afb0be07cc
Source dataset
uspto-grants-1989_01
Patent number
US04795748

Reaction notes

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