Hydrochloric Acid → HCID 2115073, compound

HRID 2291434Notes

Reaction equation

HRID 2291434 reaction equation
ClCC([NH:5][CH2:6][C:7]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[CH:10]=[CH:9][C:8]=1[OH:16])=O.Cl.O.C(=O)(O)[O-].[Na+]>C(O)C>[NH2:5][CH2:6][C:7]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[CH:10]=[CH:9][C:8]=1[OH:16]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 5115272-chloro-N-(2-hydroxy-5-nitrobenzyl)acetamideHCID 516892Sodium Bicarbonate

Product 1

HCID 2115073HCID 2115073, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

12.2 g (0.056 mole) of chloroacetamido compound of step 1 is heated in 100 ml ethanol and 30 ml concentrated hydrochloric acid for 4 hours accompanied by refluxing. After dilution with water, it is neutralized with sodium bicarbonate and the precipitate is separated by suction, accompanied by rewashing with water. The residue is purified by means of reprecipitation. 3 g of the substance is dissolved hot in 25 ml water/5 ml glacial acetic acid. After cooling, it is filtrated and the filtrate is neutralized with ammonia. The pure amimomethyl compound separates out, it is isolated by means of suction and washed with water and isopropanol.

Workup

  1. temperatureby refluxing
  2. customthe precipitate is separated by suction
  3. customThe residue is purified by means of reprecipitation
  4. dissolution3 g of the substance is dissolved hot in 25 ml water/5 ml glacial acetic acid
  5. temperatureAfter cooling
  6. filtrationit is filtrated
  7. customit is isolated by means of suction
  8. washwashed with water and isopropanol

Sources & evidence

ORD record
ord-6ad62a101de343149ac5beab4274fd55
Source dataset
uspto-grants-1989_01
Patent number
US04797130

Reaction notes

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