4-Nitrophenethyl bromide → HCID 21278911, compound

HRID 2291558Notes

Reaction equation

HRID 2291558 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.[N+:17]([C:20]1[CH:28]=[CH:27][C:23]([CH2:24][CH2:25]Br)=[CH:22][CH:21]=1)([O-:19])=[O:18].C(=O)(O)[O-].[Na+]>>[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N:11]1[CH2:16][CH2:15][N:14]([CH2:25][CH2:24][C:23]2[CH:22]=[CH:21][C:20]([N+:17]([O-:19])=[O:18])=[CH:28][CH:27]=2)[CH2:13][CH2:12]1

Participants

4

Reactant 3

HCID 792664-Nitrophenethyl bromideHCID 516892Sodium BicarbonateHCID 27713311-(2-Chloro-4-nitrophenyl)piperazine

Product 1

HCID 21278911HCID 21278911, compound

Procedure

The title compound, m.p. 102°-4°, was prepared similarly to the procedure of Example 1(A) from 1-(2-chloro-4-nitrophenyl)piperazine (1.2 g), 4-nitrophenethyl bromide (1.15 g) and sodium bicarbonate (0.85 g). The yield of the title compound was 0.37 g (from ethyl acetate), m.p. 100°-102°. A second batch had an m.p. of 102°-4° (from ethyl acetate/methanol)

Sources & evidence

ORD record
ord-18210238328b4035a26801c1df91c9e5
Source dataset
uspto-grants-1989_01
Patent number
US04797401

Reaction notes

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