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To a stirred suspension of zinc powder (0.39 g, 5.94 mmol) in THF (15 mL) was slowly added TiCl4 (0.33 mL, 2.97 mmol) via syringe at RT under a nitrogen atmosphere. The mixture was heated at reflux for 2 h. A solution of N-(4-{[4-(methyloxy)phenyl]carbonyl}phenyl)acetamide (56) (0.20 g, 0.74 mmol) and 3,3,5,5-tetramethylcyclohexanone (0.35 g, 2.23 mmol) in THF (4 mL) was added to the mixture. The reaction mixture was heated at reflux with stirring under a nitrogen atmosphere for 1 h. The reaction mixture was allowed to cool to room temperature. To the reaction mixture was slowly added 10% aqueous K2CO3 (15 mL). The reaction mixture was filtered through a pad of Celite and the pad was washed with EtOAc (100 mL). The filtrate was transferred to a separatory funnel and the layers were separated. The aqueous layer was further extracted with EtOAc (25 mL). The combined organic phase was washed with water, brine, dried (Na2SO4) filtered, and the filtrate was concentrated to give the crude product as yellow oil. The crude product was purified by chromatography on a silica gel column eluted with a gradient from hexanes to 40% EtOAc:hexanes to give 0.27 g (93%) of compound 57 as colorless viscous oil. 1H NMR (400 MHz, CDCl3): δ 0.91 (s, 6H), 0.92 (s, 6H), 1.27 (s, 2H), 1.96 (s, 2H), 1.97 (s, 2H), 2.16 (s, 3H), 3.78 (s, 3H), 6.80 (d, J=8.6 Hz, 2H), 7.06 (d, J=8.8 Hz, 2H), 7.10 (d, J=8.5 Hz, 2H), 7.39 (d, J=8.5 Hz, 2H). LCMS (ESI): m/z 392 (M+H)+, 390 (M−H)−.

1. customat RT
2. temperatureThe mixture was heated
3. temperatureat reflux for 2 h
4. temperatureThe reaction mixture was heated
5. temperatureat reflux
6. filtrationThe reaction mixture was filtered through a pad of Celite
7. washthe pad was washed with EtOAc (100 mL)
8. customThe filtrate was transferred to a separatory funnel
9. customthe layers were separated
10. extractionThe aqueous layer was further extracted with EtOAc (25 mL)
11. washThe combined organic phase was washed with water, brine
12. dry with materialdried (Na2SO4)
13. filtrationfiltered
14. concentrationthe filtrate was concentrated
15. customto give the crude product as yellow oil
16. customThe crude product was purified by chromatography on a silica gel column
17. washeluted with a gradient from hexanes to 40% EtOAc