Hydrochloric Acid → 5-(Trifluoromethyl)isoxazol-3-ylamine

HRID 2291706Notes

Reaction equation

HRID 2291706 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[O:7][N:6]=[C:5]([NH:8]C(=O)N(C)C)[CH:4]=1.Cl>>[F:1][C:2]([F:15])([F:14])[C:3]1[O:7][N:6]=[C:5]([NH2:8])[CH:4]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 156138493-Dimethylcarbamoylamino-5-trifluoromethylisoxazole

Product 1

HCID 156138795-(Trifluoromethyl)isoxazol-3-ylamine

Procedure

A mixture of 5-trifluormethyl-3-dimethylcarbamoylaminoisoxazole (1.15 g, 0.005 mole) and 36% hydrochloric acid (10 eq.) were reacted at 100° C. for 10 hours. The reaction mixture was worked up in the usual way to give the crude title compound. Crude yield: 0.20 g (26%).

Workup

  1. customwere reacted at 100° C. for 10 hours

Sources & evidence

ORD record
ord-53447d87f32b4ca29ed4f5a1e8e043b8
Source dataset
uspto-grants-1989_01
Patent number
US04797492

Reaction notes

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