Ethylamine hydrochloride → HCID 53902970, compound

HRID 2291819Notes

Reaction equation

HRID 2291819 reaction equation
[Na].[K].[CH2:3]([S:5][CH2:6][C@H:7]([CH3:16])[C@@H:8]([OH:15])[C@H:9]([NH:13][CH3:14])[C:10]([OH:12])=[O:11])C.Cl.CN.[Cl-].[NH4+].N[CH:23](C(O)C(C)CSC)C(O)=O.Cl.C(N)C>>[CH2:14]([NH:13][CH:9]([CH:8]([OH:15])[CH:7]([CH3:16])[CH2:6][S:5][CH3:3])[C:10]([OH:12])=[O:11])[CH3:23]

Participants

8

Reactant 7

HCID 11198Ethylamine hydrochlorideHCID 25517Ammonium ChlorideHCID 5360545Sodium2×HCID 5462222PotassiumHCID 6364545Methylamine hydrochlorideHCID 14347892HCID 14347892, compoundHCID 19837869HCID 19837869, compound

Product 1

HCID 53902970HCID 53902970, compound

Procedure

For example, when sodium (or potassium) ethylmercaptide was used in place of the sodium methylmercaptide in Step A, one obtained (2S, 3R, 4R)-5-(ethylthio)-3-hydroxy-4-methyl-2-(methylamino)pentanoic acid. Likewise, when the methylamine hydrochloride of Step H was replaced by ammonium chloride, (2S, 3R, [4R]4S)-2-amino-3-hydroxy-4-methyl-5-(methylthio)-pentanoic acid was obtained, and when ethylamine hydrochloride was used, (2A, 3R, [4R]4S)-2-(ethylamino)-3-hydroxy-4-methyl-5-(methyl-thio)pentanoic acid was obtained.

Workup

  1. customwas obtained

Sources & evidence

ORD record
ord-f23d690013e24136862411c2c7809c5f
Source dataset
uspto-grants-1989_01
Patent number
US04798823

Reaction notes

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