Dimethyl Sulfoxide → HCID 14326855, compound

HRID 2291947Notes

Reaction equation

HRID 2291947 reaction equation
Cl.C1(S(Cl)(=O)=O)C2C(=CC=CC=2)C=CN=1.[CH:16]1[C:25]2[CH:24]=[CH:23][CH:22]=[C:21]([S:26]([N:29]3[CH2:33][CH2:32][CH:31]([OH:34])[CH2:30]3)(=[O:28])=[O:27])[C:20]=2[CH:19]=[CH:18][N:17]=1.C(Cl)(=O)C(Cl)=O.CS(C)=O>ClCCl>[CH:16]1[C:25]2[CH:24]=[CH:23][CH:22]=[C:21]([S:26]([N:29]3[CH2:33][CH2:32][C:31](=[O:34])[CH2:30]3)(=[O:27])=[O:28])[C:20]=2[CH:19]=[CH:18][N:17]=1

Participants

6

Reactant 4

HCID 679Dimethyl SulfoxideHCID 65578Oxalyl chlorideHCID 19796336HCID 19796336, compoundHCID 21278385HCID 21278385, compound

Product 1

HCID 14326855HCID 14326855, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Substantially the same procedures as in Example 1 were repeated except that 2.64 g of 1-isoquinolinesulfonyl chloride hydrochloride was used in place of 6.0 g of 1-chloro-5-isoquinolinesulfonyl chloride hydrochloride and that 2.22 g of the thus obtained 1-(5-isoquinolinesulfonyl)-3-hydroxypyrrolidine was reacted in dichloromethane with 1.08 g of oxalyl chloride and 0.67 g of dimethylsulfoxide. There was obtained 1-(5-isoquinolinesulfonyl)-3-pyrrolidone.

Sources & evidence

ORD record
ord-924bc5ae27194198a9520ee1f366020a
Source dataset
uspto-grants-1989_01
Patent number
US04798897

Reaction notes

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