Ethyl Acetate → HCID 15711991, compound

HRID 2292044Notes

Reaction equation

HRID 2292044 reaction equation
[C:1]([C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][C:8]([CH3:15])([CH3:14])[CH:9]3[O:13][CH:10]32)=[CH:5][CH:4]=1)#[N:2].C(OCC)(=O)C.[OH-].[NH4+:23]>C(O)C>[NH2:23][C@@H:10]1[C:11]2[C:6](=[CH:5][CH:4]=[C:3]([C:1]#[N:2])[CH:12]=2)[CH2:7][C:8]([CH3:15])([CH3:14])[C@H:9]1[OH:13]

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 14923Ammonium HydroxideHCID 15711990HCID 15711990, compound

Product 1

HCID 15711991HCID 15711991, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 7-cyano-1,2-epoxy-3,3-dimethyl-1,2,3,4-tetrahydronaphthalene (3.5 g) in ethanol (50 ml) and ammonium hydroxide solution (100 ml) was stirred at room temperature for 10 days. Ethyl acetate (50 ml) was added and the mixture extracted with dilute hydrochloric acid. The acidic extracts were made basic with sodium hydroxide solution, and extracted with ethyl acetate. The organic extracts were washed with water, then brine, and dried over sodium sulphate.

Workup

  1. extractionthe mixture extracted with dilute hydrochloric acid
  2. extractionextracted with ethyl acetate
  3. washThe organic extracts were washed with water
  4. dry with materialbrine, and dried over sodium sulphate

Sources & evidence

ORD record
ord-b0f0266beae4429f82cdc37813498de5
Source dataset
uspto-grants-1989_01
Patent number
US04800212

Reaction notes

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