Sodium Iodide → HCID 14349730, compound

HRID 2292051Notes

Reaction equation

[C:1]([O:4][CH2:5][C:6]1[CH2:13][S:12][C@H:11]2[N:8]([C:9](=[O:18])[C@H:10]2[NH:14][C:15]([NH2:17])=[S:16])[C:7]=1[C:19]([O:21][CH:22]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:20])(=[O:3])[CH3:2].[I-].[Na+].[C:37](=O)([O-])[O-].[K+].[K+].[C:43](#N)[CH3:44]>>[C:1]([O:4][CH2:5][C:6]1[CH2:13][S:12][C@H:11]2[N:8]([C:9](=[O:18])[C@H:10]2[NH:14][C:15]2[S:16][CH:37]=[C:43]([CH3:44])[N:17]=2)[C:7]=1[C:19]([O:21][CH:22]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)=[O:20])(=[O:3])[CH3:2]

Participants

Reactant 4

HCID 5238Sodium Iodide

HCID 6342Acetonitrile

HCID 11430Potassium Carbonate

HCID 14349717HCID 14349717, compound

Product 1

HCID 14349730HCID 14349730, compound

Procedure

A mixture of 91 mg of (6R-trans)-3-[(acetyloxyl)methyl]-7-[(aminothioxomethyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, diphenylmethyl ester, 33 mg of sodium iodide, 20 mg of potassium carbonate and 2 ml of acetonitrile was reacted as described in Example 2, giving the desired compound.

Workup

customwas reacted

Sources & evidence

ORD record: ord-fc9f69230cd548c2abbb4398d9f6fa6f
Source dataset: uspto-grants-1989_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04800199

Reaction notes

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