Trifluoroacetic acid → HCID 14349742, compound

HRID 2292056Notes

Reaction equation

HRID 2292056 reaction equation
[C:1]([O:4][CH2:5][C:6]1[CH2:13][S:12][C@H:11]2[N:8]([C:9](=[O:21])[C@H:10]2[NH:14][C:15]2[S:16][CH:17]=[C:18]([CH3:20])[N:19]=2)[C:7]=1[C:22]([O:24]C(C1C=CC=CC=1)C1C=CC=CC=1)=[O:23])(=[O:3])[CH3:2].FC(F)(F)C(O)=O.C1(OC)C=CC=CC=1>ClCCl>[C:1]([O:4][CH2:5][C:6]1[CH2:13][S:12][C@H:11]2[N:8]([C:9](=[O:21])[C@H:10]2[NH:14][C:15]2[S:16][CH:17]=[C:18]([CH3:20])[N:19]=2)[C:7]=1[C:22]([OH:24])=[O:23])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 14349730HCID 14349730, compound

Product 1

HCID 14349742HCID 14349742, compoundYield 84.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 210 mg of (6R-trans)-3-[(acetyloxy)methyl]-7-[(4-methyl-2-thiazolyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, diphenylmethyl ester, trifluoroacetic acid and anisole in dichloromethane was reacted as described in Example 11, giving 123 mg of the desired product.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-bfba5e8d13fd434b8857b89a18bd9e56
Source dataset
uspto-grants-1989_01
Patent number
US04800199

Reaction notes

Loading…