反应详情

2,5,6-Trimethylbenzimidazole (9.4 g) and sodium hydride (2.1 g, 80% suspension in oil) were sonicated in dry tetrahydrofuran (150 ml) for 1 hour. Ethyl 2-bromoacetate (9.8 g) in dry tetrahydrofuran (50 ml) was added and the reaction sonicated at 40° C. for 2 hours. The reaction was partitioned between ethyl acetate (300 ml) and water (100 ml), the organic phase dried over magnesium sulphate and the solvent removed under reduced pressure to yield ethyl 2-(2,5,6-trimethylbenzimidazol-1-yl)acetate (13.5 g).

1. customthe reaction sonicated at 40° C. for 2 hours
2. customThe reaction was partitioned between ethyl acetate (300 ml) and water (100 ml)
3. dry with materialthe organic phase dried over magnesium sulphate
4. customthe solvent removed under reduced pressure