Iodoethane → 1-Ethoxy-3-fluorobenzene

HRID 2292257Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.[CH2:9](I)[CH3:10]>>[F:1][C:2]1[CH:3]=[C:4]([O:8][CH2:9][CH3:10])[CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 6340Iodoethane

HCID 97433-Fluorophenol

Product 1

HCID 1363011-Ethoxy-3-fluorobenzene

Procedure

3-fluoro-phenol and ethyl iodide were reacted to form 3-fluoro-ethoxy benzene with a refractive index of nD25 =1.4823 which was reacted with nitric acid to obtain 2-ethoxy-4-fluoronitro benzene with a melting point of 28°~30° C. which was reacted to obtain 0-(4-nitro-3-ethoxy-phenyl)-hydroxylamine melting at 97°~98° C.

Sources & evidence

ORD record: ord-a3f6604296374e928ce3cd1f97c54e7b
Source dataset: uspto-grants-1989_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04801717

Reaction notes

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