Glycidol → HCID 21478985, compound

HRID 2292659Notes

Reaction equation

HRID 2292659 reaction equation
[N:1]1([CH2:6][C:7]2[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=2)[CH:5]=[CH:4][CH:3]=[N:2]1.[CH2:14]1[O:16][CH:15]1[CH2:17][OH:18]>[Cl-].C[N+](C)(C)C.C1(C)C(C)=CC=CC=1>[OH:16][CH:15]([CH2:14][O:13][C:10]1[CH:11]=[CH:12][C:7]([CH2:6][N:1]2[CH:5]=[CH:4][CH:3]=[N:2]2)=[CH:8][CH:9]=1)[CH2:17][OH:18]

Participants

5

Reactant 2

HCID 11164GlycidolHCID 1334121-(4-Hydroxybenzyl)pyrazole

Product 1

HCID 21478985HCID 21478985, compound

Reagents, catalysts & solvents 2

HCID 6379Tetramethylammonium chlorideCatalystHCID 7237O-XyleneSolvent

Procedure

A mixture of 4-(1-pyrazolyl)methylphenol [this was obtained by the same method as described in the square parentheses in Production Example 1] (2 g), glycidol (936 g), dry xylene (10 ml) and a catalytic amount of tetramethylammonium chloride was stirred at 60° C. for 6 hours. The reaction mixture was then subjected to silica gel chromatography, which afforded 941 mg of 2-hydroxy-3-[4-(1-pyrazolyl)methylphenoxy]-propanol.

Workup

  1. customthis was obtained by the same method

Sources & evidence

ORD record
ord-cc3b722907a44cb89e50ac28aeb1879d
Source dataset
uspto-grants-1997_11
Patent number
US05684022

Reaction notes

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