Methyl iodide → HCID 21475738, compound

HRID 2293038Notes

Reaction equation

HRID 2293038 reaction equation
[CH2:1]([N:3]([CH3:7])[C:4]([NH2:6])=[S:5])[CH3:2].C[I:9].[C:10](OCC)(=O)C>CN(C)C=O>[IH:9].[CH2:1]([N:3]([CH3:7])[C:4](=[NH:6])[S:5][CH3:10])[CH3:2]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 8857Ethyl AcetateHCID 13848133HCID 13848133, compound

Product 1

HCID 21475738HCID 21475738, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

5.8 g (49 mmol) of N-ethyl-N-methylthiourea was dissolved in 10 ml of N,N-dimethylformamide. 8.8 g (62 mmol) of methyl iodide was added at room temperature, and the mixture was stirred at room temperature for 15 hours. 500 ml of ethyl acetate was added to the mixture, and precipitated crystals were collected by filtration and then washed with ethyl acetate to obtain 3.1 g of N-ethyl-N-methyl-S-methylisothiourea hydroiodide as pale yellow crystals.

Workup

  1. customprecipitated crystals
  2. filtrationwere collected by filtration
  3. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-018e00fdf6b040669b44652b708ea397
Source dataset
uspto-grants-1997_11
Patent number
US05686390

Reaction notes

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