1-Fluoro-2-nitrobenzene → Benzenamine, N-methyl-2-nitro-

Methylamine hydrochloride (2.7 g) and a 10% aqueous solution of sodium hydroxyde (30 ml) were added to a solution of 1-fluoro-2-nitrobenzene (2.82 g) in THF (20 ml). The mixture was kept at 23° for 24 h. The reaction mixture was then concentrated in vacuo, taken up with 10% aqueous sodium hydroxide (30 ml) and extracted with EA (3×30 ml). The combined organic layers were washed with a saturated ammonium chloride solution (50 ml), brine (50 ml) and dried. Evaporation of the solvent gave the title compound as an orange oil (2.894 g).

1. concentrationThe reaction mixture was then concentrated in vacuo
2. extractionextracted with EA (3×30 ml)
3. washThe combined organic layers were washed with a saturated ammonium chloride solution (50 ml), brine (50 ml)
4. customdried
5. customEvaporation of the solvent

ORD record

ord-fe1565a7fa9242fab8b27da25e0bd0c6

Source dataset

uspto-grants-1997_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05686449