Phenethylamine → N-(2-phenylethyl)acetamide

HRID 2293122Notes

Reaction equation

HRID 2293122 reaction equation
[CH2:1]([NH2:9])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(N(CC)CC)C.[C:17](Cl)(=[O:19])[CH3:18]>ClCCl>[C:3]1([CH2:2][CH2:1][NH:9][C:17](=[O:19])[CH3:18])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 1001PhenethylamineHCID 6367Acetyl chlorideHCID 8471Triethylamine

Product 1

HCID 70143N-(2-phenylethyl)acetamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

12.6 ml of phenethylamine(0.1M) and 14 ml of triethylamine(0.1M) were dissolved in 100 ml of dichloro-methane; and 6.9 ml of acetyl chloride(0.1M) was dropwise added thereto while maintaining the temperature of the reaction system below 0° C., followed by stirring at a room temperature for 10 minutes. The reaction solution was washed with water, dried over anhydrous magnesium sulfate and concentrated under a reduced pressure to give 14.23 g Of the title compound as white solids.

Workup

  1. temperaturewhile maintaining the temperature of the reaction system below 0° C.
  2. washThe reaction solution was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated under a reduced pressure

Sources & evidence

ORD record
ord-5ba759dc176a4b8fba363fea019e4a7e
Source dataset
uspto-grants-1997_11
Patent number
US05686458

Reaction notes

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