Tetrahydrofuran → HCID 21476517, compound

HRID 2293134Notes

Reaction equation

HRID 2293134 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].O1CCCC1.C([O:14][C:15]([CH2:17][NH:18][CH:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[CH3:27])[CH3:20])=O)C>O>[OH:14][CH2:15][CH2:17][NH:18][CH:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[CH3:27])[CH3:20]

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 21226445Aluminium lithium hydrideHCID 21476429Glycine, N-[1-(2-methylphenyl)ethyl]-, ethyl ester

Product 1

HCID 21476517HCID 21476517, compoundYield 73.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a mixture of 3.8 g of lithium aluminium hydride (0.1M) and 150 ml of tetrahydrofuran, 23.3 g of the compound (0.105M) prepared in Step 2 above was dropwise added at room temperature and stirred for 30 minutes. The resultant was added with water and solids produced were filtered. The filtrate was dried over anhydrous sodium sulfate and concentrated under a reduced pressure, to give 13.8 g of the title compound.

Workup

  1. additionabove was dropwise added at room temperature
  2. customproduced
  3. filtrationwere filtered
  4. dry with materialThe filtrate was dried over anhydrous sodium sulfate
  5. concentrationconcentrated under a reduced pressure

Sources & evidence

ORD record
ord-d27c09a32e4e4329baf030e0a5a47bc3
Source dataset
uspto-grants-1997_11
Patent number
US05686458

Reaction notes

Loading…