N-Methylaniline → HCID 70198295, compound

HRID 2293139Notes

Reaction equation

HRID 2293139 reaction equation
[Cl:1][C:2]1[N:11]=[C:10]([N:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:22][NH:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>CN(C)C=O>[ClH:1].[CH3:22][N:23]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:2]1[N:11]=[C:10]([N:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

4

Reactant 2

HCID 7515N-MethylanilineHCID 226926412-Chloro-4-(3,4-dihydroisoquinolin-2(1H)-yl)quinazoline

Product 1

HCID 70198295HCID 70198295, compoundYield 42%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In accordance with the same procedures as in Example 18, except that to a mixture of 0.9 g of the compound(3 mM) prepared in Example 1 and 15 ml of dimethylformamide, 0.4 ml of N-methylaniline(3.6 mM) was added, 0.51 g of the title compound was prepared.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-c8d3d44041a24bfc9e239c416a352415
Source dataset
uspto-grants-1997_11
Patent number
US05686458

Reaction notes

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