反应详情

A solution of ethyl 3-formyl-4,6-dichloroindole-2-carboxylate (5.0 g) in dry DMF (30 ml) was added to a suspension of sodium hydride (0.629 g; 80% suspension in mineral oil) in dry DMF (10 ml) under nitrogen at 0°. The reaction was stirred at this temperature for 45 min then phenylsulfonyl chloride (2.5 ml) was added giving a yellow precipitate. The reaction was allowed to warm slowly to room temperature, stirred for a further 14 h then poured into water (250 ml). The solid was filtered, washed with water and then with ethyl acetate to give the title compound (4.493 g,) as a white solid, m.p. 225.8°-226.3°.

1. customgiving a yellow precipitate
2. stirringstirred for a further 14 h
3. filtrationThe solid was filtered
4. washwashed with water