Water → HCID 23667855, compound

HRID 2293297Notes

Reaction equation

HRID 2293297 reaction equation
[OH-].[Na+:2].[C:3]12([NH:13][C:14]([C:16]#[C:17][C:18]3[C:26]4[C:21](=[CH:22][C:23]([Cl:28])=[CH:24][C:25]=4[Cl:27])[NH:20][C:19]=3[C:29]([O:31]CC)=[O:30])=[O:15])[CH2:12][CH:7]3[CH2:8][CH:9]([CH2:11][CH:5]([CH2:6]3)[CH2:4]1)[CH2:10]2.O>C(O)(C)C>[Na+:2].[C:3]12([NH:13][C:14]([C:16]#[C:17][C:18]3[C:26]4[C:21](=[CH:22][C:23]([Cl:28])=[CH:24][C:25]=4[Cl:27])[NH:20][C:19]=3[C:29]([O-:31])=[O:30])=[O:15])[CH2:12][CH:7]3[CH2:8][CH:9]([CH2:11][CH:5]([CH2:6]3)[CH2:4]1)[CH2:10]2

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 21476641HCID 21476641, compound

Product 1

HCID 23667855HCID 23667855, compoundYield 93.6%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
60 °C

Procedure

Sodium hydroxide (59 mg) was added to a solution of Example 18 (170 mg) in isopropyl alcohol (5.4 ml) and the reaction was heated at 60° C. for 3 h. After cooling, water (6 ml) was added and the resulting yellow precipitate was filtered and washed well with more water, then dried to furnish the title compound (157 mg,) as a white solid.

Workup

  1. temperatureAfter cooling
  2. filtrationthe resulting yellow precipitate was filtered
  3. washwashed well with more water
  4. customdried

Sources & evidence

ORD record
ord-395557dd82f944ea953801dec850b685
Source dataset
uspto-grants-1997_11
Patent number
US05686461

Reaction notes

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