Hydrochloric Acid → HCID 131720304, compound

HRID 2293421Notes

Reaction equation

HRID 2293421 reaction equation
[ClH:1].C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl.[CH3:16][O:17][C:18]1[CH:19]=[C:20]([C:28](=[O:46])[CH2:29][CH:30]([NH:38][C:39](=[O:45])[C@@H:40]2[CH2:44][CH2:43][CH2:42][NH:41]2)[CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][N:33]=2)[CH:21]=[C:22]([O:26][CH3:27])[C:23]=1[O:24][CH3:25]>CCOCC>[ClH:1].[ClH:1].[CH3:27][O:26][C:22]1[CH:21]=[C:20]([C:28](=[O:46])[CH2:29][CH:30]([NH:38][C:39](=[O:45])[C@@H:40]2[CH2:44][CH2:43][CH2:42][NH:41]2)[CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][N:33]=2)[CH:19]=[C:18]([O:17][CH3:16])[C:23]=1[O:24][CH3:25]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 131720305HCID 131720305, compound

Product 1

HCID 131720304HCID 131720304, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Following the procedure described in Example 120, the coupling of N-[2-(3,4,5-trimethoxyphenyl)-2-oxoethyl] -L-proline hydrochloride (300 mg, 0.83 mmol) and 2(2-aminoethyl)pyridine (0.4 mL, 2.5 mmol ) provided, after treatment with HCl in Et2O, 193 mg of the dihydrochloride salt of L-proline, 1-[2-(3,4,5-trimethoxyphenyl)-2-oxoethyl] 2-(pyrid-2-yl)ethylamide as a powder.

Sources & evidence

ORD record
ord-3e774cdc229c4aa8b08edc0c4f7852c4
Source dataset
uspto-grants-1997_11
Patent number
US05686424

Reaction notes

Loading…