Hydrochloric Acid → HCID 67621026, compound

HRID 2293424Notes

Reaction equation

HRID 2293424 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:14](=[O:36])[CH2:15][C@@:16]([NH:28][C:29](=[O:35])[C@@H:30]2[CH2:34][CH2:33][CH2:32][NH:31]2)([C:18]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH:21]=[CH:20][CH:19]=2)[CH3:17])[CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11]>CCOCC>[ClH:1].[CH3:13][O:12][C:8]1[CH:7]=[C:6]([C:14](=[O:36])[CH2:15][C@@:16]([NH:28][C:29](=[O:35])[C@@H:30]2[CH2:34][CH2:33][CH2:32][NH:31]2)([C:18]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH:21]=[CH:20][CH:19]=2)[CH3:17])[CH:5]=[C:4]([O:3][CH3:2])[C:9]=1[O:10][CH3:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67621027HCID 67621027, compound

Product 1

HCID 67621026HCID 67621026, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Following the procedure described in Example 120, the coupling of N-[2-(3,4,5-trimethoxyphenyl)-2-oxoethyl]-L-proline hydrochloride (250 mg, 0.69 mmol) and (R)-1-(1-naphthyl)ethylamine (0.34 mL, 2.1 mmol) provided, after treatment with HCl in Et2O, 137 mg of the hydrochloride salt of L-proline, 1-[2-(3,4,5-trimethoxyphenyl)-2-oxoethyl] (R)-1-(1-naphthyl)ethylamide as a powder.

Sources & evidence

ORD record
ord-34a4c652a00b41228802d5988936081a
Source dataset
uspto-grants-1997_11
Patent number
US05686424

Reaction notes

Loading…