Hydrochloric Acid → HCID 67619574, compound

HRID 2293427Notes

Reaction equation

HRID 2293427 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:14](=[O:30])[CH2:15][C:16]2([NH:22][C:23](=[O:29])[C@@H:24]3[CH2:28][CH2:27][CH2:26][NH:25]3)[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11]>CCOCC>[ClH:1].[CH3:13][O:12][C:8]1[CH:7]=[C:6]([C:14](=[O:30])[CH2:15][C:16]2([NH:22][C:23](=[O:29])[C@@H:24]3[CH2:28][CH2:27][CH2:26][NH:25]3)[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[CH:5]=[C:4]([O:3][CH3:2])[C:9]=1[O:10][CH3:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67619575HCID 67619575, compound

Product 1

HCID 67619574HCID 67619574, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Following the procedure described in Example 120, the coupling of N-[2-(3,4,5-trimethoxyphenyl)-2-oxoethyl] -L-proline hydrochloride (250 mg, 0.69 mmol) and cyclohexylamine (0.24 mL, 2.1 mmol) provided, after treatment with HCl in Et2O, 147 mg of the hydrochloride salt of L-proline, 1-[2-(3,4,5-trimethoxyphenyl)-2-oxoethyl] cyclohexylamide as a powder.

Sources & evidence

ORD record
ord-06a4a475ca3644deb670cff26b1f1870
Source dataset
uspto-grants-1997_11
Patent number
US05686424

Reaction notes

Loading…