反应详情

In a stream of argon, 0.30 g of metallic sodium was added to 5 ml of methanol under ice-cooling, the mixture was stirred at room temperature for a while and then 1.00 g of 4-chloro-2-methoxy-5-nitrobenzoic acid was added to the resulting solution in small portions, followed by stirring at 80° C. for 8 hours. After completion of the reaction, the reaction solution was poured into 1N hydrochloric acid aqueous solution, and the thus precipitated product of interest was collected by filtration, washed with water and then dried under a reduced pressure to give 0.80 g of 2,4-dimethoxy-5-nitrobenzoic acid.

1. temperaturecooling
2. stirringby stirring at 80° C. for 8 hours
3. customAfter completion of the reaction
4. filtrationthe thus precipitated product of interest was collected by filtration
5. washwashed with water
6. customdried under a reduced pressure