反应详情

A 7.00 g portion of 2,4-dimethoxy-5-nitrobenzoic acid was dissolved in 2-butanone, and 9.90 g of potassium carbonate and 3.6 ml of dimethyl sulfate were added, followed by 3 hours of heating under reflux. After completion of the reaction, the reaction solution was poured into 1N hydrochloric acid aqueous solution, and the thus precipitated product of interest was collected by filtration, washed with water and then dried under a reduced pressure to give 5.45 g of methyl 2,4-dimethoxy-5-nitrobenzoate.

1. temperatureof heating
2. temperatureunder reflux
3. customAfter completion of the reaction
4. filtrationthe thus precipitated product of interest was collected by filtration
5. washwashed with water
6. customdried under a reduced pressure