反应详情

A 0.56 g portion of methyl 5-chloro-2,4-dimethoxybenzoate was dissolved in 5 ml of tetrahydrofuran, and 10 ml of 2N sodium hydroxide aqueous solution was added, followed by 4 hours of heating under reflux. After completion of the reaction, the reaction solution was poured into 1N hydrochloric acid aqueous solution, and the thus precipitated product of interest was collected by filtration, washed with water and then dried under a reduced pressure to give 0.45 g of 5-chloro-2,4-dimethoxybenzoic acid.

1. temperatureof heating
2. temperatureunder reflux
3. customAfter completion of the reaction
4. filtrationthe thus precipitated product of interest was collected by filtration
5. washwashed with water
6. customdried under a reduced pressure