反应详情

A 3.20 g portion of methyl 4-isopropoxy-2-methoxybenzoate was dissolved in 20 ml of tetrahydrofuran, and 30 ml of 2N sodium hydroxide aqueous solution was added, followed by 2 hours of heating under reflux. After completion of the reaction, the reaction solution was poured into 1N hydrochloric acid aqueous solution, extracted with chloroform and dried over anhydrous sodium sulfate. Then, the solvent was evaporated under a reduced pressure to give 2.60 g of 4-isopropoxy-2-methoxybenzoic acid.

1. temperatureof heating
2. temperatureunder reflux
3. customAfter completion of the reaction
4. extractionextracted with chloroform
5. dry with materialdried over anhydrous sodium sulfate
6. customThen, the solvent was evaporated under a reduced pressure