Diisopropylethylamine → HCID 57757887, compound

HRID 229365Notes

Reaction equation

HRID 229365 reaction equation
Cl[C:2]1[N:6]2[CH:7]=[CH:8][C:9]([C:11]3C=NC=C[CH:16]=3)=[CH:10][C:5]2=[N:4][C:3]=1[NH:17][C:18]([NH:20][CH2:21][CH3:22])=[O:19].ClCC(NC(NCC)=O)=[O:26].C(N(C(C)C)C(C)C)C>CN(C)C=O.O>[C:11]([C:9]1[CH:8]=[CH:7][N:6]2[CH:2]=[C:3]([NH:17][C:18]([NH:20][CH2:21][CH3:22])=[O:19])[N:4]=[C:5]2[CH:10]=1)(=[O:26])[CH3:16]

Participants

6

Reactant 3

HCID 81531DiisopropylethylamineHCID 23047901-(2-Chloro-acetyl)-3-ethyl-ureaHCID 11483894HCID 11483894, compound

Product 1

HCID 57757887HCID 57757887, compoundYield 156.7%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

A mixture of compound (2) (0.4 g, 1.27 mmol), N-(chloroacetyl)-N′-ethylurea (0.3 g, 1.8 mmol) and N-ethyldiisopropylamine (0.33 g, 2.5 mmol) in dry DMF (“dimethylformamide”) (5 mL) was stirred at room temperature overnight. The mixture was diluted with water to give 0.49 g of (3) as a solid.

Sources & evidence

ORD record
ord-7324c87f6dfd42488cf94939bce0d487
Source dataset
uspto-grants-2009_07
Patent number
US07563788B2

Reaction notes

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