Sodium Iodide → HCID 54724936, compound

HRID 2293691Notes

Reaction equation

HRID 2293691 reaction equation
Cl[CH2:2][CH2:3][CH2:4][S:5]([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH:15]([CH:30]2[CH2:32][CH2:31]2)[C:16]2[C:21](=[O:22])[O:20][C:19]3[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][C:18]=3[C:17]=2[OH:29])[CH:10]=1)(=[O:7])=[O:6].[Na+].[I-:34]>C(Cl)Cl>[I:34][CH2:2][CH2:3][CH2:4][S:5]([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH:15]([CH:30]2[CH2:32][CH2:31]2)[C:16]2[C:21](=[O:22])[O:20][C:19]3[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][C:18]=3[C:17]=2[OH:29])[CH:10]=1)(=[O:7])=[O:6]

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 54724869HCID 54724869, compound

Product 1

HCID 54724936HCID 54724936, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 96 mg (2 mmol) of the title compound of Example 331 is added 34 mg of NaI and 2 ml of methylene chloride. The reaction mixture is heated at reflux for 18 hours. The solution is cooled to room temperature and evaporated to dryness under vacuum. The residue is distributed between water and methylene chloride, the organic solution is washed twice with water, dried over anhydrous sodium sulfate, filtered and evaporated to dryness to give the title compound as an amorphous solid.

Workup

  1. temperatureThe reaction mixture is heated
  2. temperatureat reflux for 18 hours
  3. customevaporated to dryness under vacuum
  4. washthe organic solution is washed twice with water
  5. dry with materialdried over anhydrous sodium sulfate
  6. filtrationfiltered
  7. customevaporated to dryness

Sources & evidence

ORD record
ord-0d0256b3e67a49fdab81e9676a17a314
Source dataset
uspto-grants-1997_11
Patent number
US05686486

Reaction notes

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