Isobutyraldehyde → HCID 9834191, compound

Acetophenone (11.433 gm, 95 mmol) was added dropwise over a five minute period to a solution of lithium bis(trimethylsilyl)amide (1.0M in THF, 100 ml, 100 mmol) in THF (50 ml) kept at -78° C. After 30 minutes, isobutyraldehyde (6.87 gm, 95 mmol) was added dropwise and stirring was continued for an additional hour. The mixture was quenched with saturated NH4Cl (100 ml), warmed to room temperature, diluted with H2O and extracted 2× with Et2O. The combined Et2O extracts were washed with brine, dried (Na2SO4), filtered and stripped to yield an oil. The oil was distilled (P=1.5 mm) and the fraction boiling between 120°-124° C. was chromatographed (flash, Merck SiO2, 15% EtOAc in hexane) to give the desired 3-hydroxy-4-methyl-1-phenyl-1-pentanone as a colorless liquid (9.13 gm, 50%)

1. customkept at -78° C
2. waitwas continued for an additional hour
3. customThe mixture was quenched with saturated NH4Cl (100 ml)
4. additiondiluted with H2O
5. extractionextracted 2× with Et2O
6. washThe combined Et2O extracts were washed with brine
7. dry with materialdried (Na2SO4)
8. filtrationfiltered
9. customto yield an oil
10. distillationThe oil was distilled (P=1.5 mm)
11. customboiling between 120°-124° C.
12. customwas chromatographed (flash, Merck SiO2, 15% EtOAc in hexane)

ORD record

ord-6971d6c733d348aa8151814d6d42a4e1

Source dataset

uspto-grants-1997_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05686433