Hydrochloric Acid → HCID 21473709, compound

HRID 2294023Notes

Reaction equation

HRID 2294023 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][N:10]2[CH2:15][CH:14]=[C:13]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:12][CH2:11]2)=[CH:4][N:3]=1.[ClH:24]>C(O)C>[ClH:24].[ClH:24].[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][N:10]2[CH2:11][CH:12]=[C:13]([CH2:16][CH2:17][C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH2:14][CH2:15]2)=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21473642HCID 21473642, compound

Product 1

HCID 21473709HCID 21473709, compoundYield 101.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 0.177 g (0.00057 mol) of 2-methyl-5-(4-phenethyl-3,6-dihydro-2H-pyridin-1-ylmethyl)-pyrimidin-4-ylamine in 10 ml of ethanol was treated with 0.16 ml (0.00057 mol) of 3.5N ethanolic hydrochloric acid. The solution was completely freed from the solvents and the residue was recrystallized from methanol/diethyl ether. 0.110 g (51%) of 2-methyl-5-(4-phenethyl-3,6-dihydro-2H-pyridin-1-ylmethyl)-pyrimidin-4-ylamine dihydrochloride was obtained as white crystals; m.p. 235°-237°.

Workup

  1. customthe residue was recrystallized from methanol/diethyl ether

Sources & evidence

ORD record
ord-16102571c90843208f3843f1934556ac
Source dataset
uspto-grants-1997_11
Patent number
US05688798

Reaction notes

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