Hydrochloric Acid → HCID 21473697, compound

HRID 2294024Notes

Reaction equation

HRID 2294024 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][N:10]2[CH2:15][CH:14]=[C:13](/[CH:16]=[CH:17]/[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:12][CH2:11]2)=[CH:4][N:3]=1.[ClH:24]>CO.ClCCl>[ClH:24].[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][N:10]2[CH2:11][CH:12]=[C:13](/[CH:16]=[CH:17]/[C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH2:14][CH2:15]2)=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21473690HCID 21473690, compound

Product 1

HCID 21473697HCID 21473697, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

A solution of 0.077 g (0.00025 mol) of (E)-2-methyl-5-(4-styryl-3,6-dihydro-2H-pyridin-1-ylmethyl)-pyrimidin-4-ylamine in 30 ml of methanol/dichloromethane 1:1 was treated with 0.07 ml (0.00026 mol) of 3.5N ethanolic hydrochloric acid. The solution was completely freed from the solvents and recrystallized from ethanol/diethyl ether. 0.046 g (54%) of (E)-2-methyl-5-(4-styryl-3,6-dihydro-2H-pyridin-1-ylmethyl)-pyrimidin-4-ylamine hydrochloride (1:1.2) was obtained as yellowish crystals; m.p. 185°-192°.

Workup

  1. customrecrystallized from ethanol/diethyl ether

Sources & evidence

ORD record
ord-cbb22afef3254abf893db57f30f9c765
Source dataset
uspto-grants-1997_11
Patent number
US05688798

Reaction notes

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