Hydrochloric Acid → HCID 21473634, compound

HRID 2294029Notes

Reaction equation

HRID 2294029 reaction equation
[CH2:1]([O:8][CH2:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][C:17]2[C:18]([NH2:24])=[N:19][C:20]([CH3:23])=[N:21][CH:22]=2)[CH2:12][CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:25].C(OCC)C>CO>[ClH:25].[ClH:25].[CH2:1]([O:8][CH2:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][C:17]2[C:18]([NH2:24])=[N:19][C:20]([CH3:23])=[N:21][CH:22]=2)[CH2:12][CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 21473635HCID 21473635, compound

Product 1

HCID 21473634HCID 21473634, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.076 g (0.000233 mol) of [5-(4-benzyloxymethyl-piperidin-1-ylmethyl)-2-methyl-pyrimidin-4-yl]-amine was dissolved in 1.2 ml of methanol and treated with 1.1 ml of 2.1M methanolic HCl. After adding some diethyl ether a colourless precipitate separated. This was filtered off under suction, washed and dried in a high vacuum. 0.044 g (47%) of [5-(4-benzyloxymethyl-piperidin-1-ylmethyl)-2-methyl-pyrimidin-4-yl]-amine dihydrochloride was obtained as colourless crystals; m.p. >247° (dec.).

Workup

  1. customseparated
  2. filtrationThis was filtered off under suction
  3. washwashed
  4. customdried in a high vacuum

Sources & evidence

ORD record
ord-123e37ef63ca43e88d2f7abf4a532f3f
Source dataset
uspto-grants-1997_11
Patent number
US05688798

Reaction notes

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