Hydrochloric Acid → HCID 21473624, compound

HRID 2294047Notes

Reaction equation

HRID 2294047 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]3)=[CH:5][CH:4]=1>C(OCC)(=O)C>[ClH:2].[Cl:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[CH2:15][NH:14][CH2:13][CH2:12]3)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21473696HCID 21473696, compound

Product 1

HCID 21473624HCID 21473624, compoundYield 200.4%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A stream of hydrogen chloride gas was conducted through a solution of 2.52 g (0.0073 mol) of tert.-butyl 6-(4-chlorophenyl)-3,4-dihydro-1H-isoquinoline-2-carboxylate in 110 ml of ethyl acetate. The reaction was followed by thin-layer chromatography. The mixture was cooled to 0° and suction filtered. 2.05 g (100%) of 6-(4-chlorophenyl)-3,4-dihydro-1H-isoquinoline hydrochloride were obtained as white crystals; sublimation at 215°-245° (dec.).

Workup

  1. temperatureThe mixture was cooled to 0°
  2. filtrationsuction filtered

Sources & evidence

ORD record
ord-6d2acdf0cf6e49c590995e1691370467
Source dataset
uspto-grants-1997_11
Patent number
US05688798

Reaction notes

Loading…