Hydrochloric Acid → HCID 21473636, compound

HRID 2294049Notes

Reaction equation

HRID 2294049 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[CH2:14][N:13]([CH2:18][C:19]2[C:20]([NH2:26])=[N:21][C:22]([CH3:25])=[N:23][CH:24]=2)[CH2:12][CH2:11]3)=[CH:4][CH:3]=1.[ClH:27]>C(O)C>[ClH:1].[ClH:27].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[CH2:14][N:13]([CH2:18][C:19]2[C:20]([NH2:26])=[N:21][C:22]([CH3:25])=[N:23][CH:24]=2)[CH2:12][CH2:11]3)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21473637HCID 21473637, compound

Product 1

HCID 21473636HCID 21473636, compoundYield 84.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 0.56 g (0.00053 mol) of crude 5-[6-(4-chlorophenyl)-3,4-dihydro-1H-isoquinolin-2ylmethyl]-2-methyl-pyrimidin-4-ylamine in 100 ml of ethanol was filtered and treated with 1.1 ml (0.00385 mol) of 3.5N ethanolic hydrochloric acid. The suspension obtained was suction filtered. 0.098 g (14%) of 5-[6-(4-chlorophenyl)-3,4-dihydro-1H-isochinolin-2-ylmethyl]-2-methyl-pyrimidin-4-ylamine dihydrochloride was obtained as white crystals; m.p. 223°-235° (dec).

Workup

  1. customThe suspension obtained
  2. filtrationfiltered

Sources & evidence

ORD record
ord-bf1556d509984dd2a8027088e6b08809
Source dataset
uspto-grants-1997_11
Patent number
US05688798

Reaction notes

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